yes , they are jumpers you can make with cable... or if you don't want it you can make other pcb.. choice is yours.
you can get 250w with this pcb. or you can increse output transistors will you get up to smoothly 400w with 2ohm loads
how many is your supply voltage? you can calculate fuse current or if you say voltage ı'll advice to you but if you want get 250w minimum 4 amps
it means 45v... and you can use 5 or 6 amp fuse
nazirdigi, ı too don't know how to bias adjustments but ı'm using transistors with no heatsinks ı they don't get heats it's ok. and this circuit's bias driver is automatic don't worry. and you can do with watt/current calculation/ per alternance/
nazirdigi, don't forget: fuses can't protects to speakers alone. for this job , various methods usable. for example; dc offset protection, peak limiter, clip limiter dc capacitacion charge protection and many more
nazdrigi your 75v is a bit high for this amp. you don't past 2x60v dc, peak limiter and clip limiter under construction and testing if ı finish ı'll share quickly. if you want work with 75vdc, you can make my other project JBL 301.1 it stands 2ohms and it delivers 400w per channel it tested by me. and capacitation charge protection is very simple, only 4sec delays after amp starts